Day 1 :
Time : 12:05-12:50
Fatemeh Bahadori has completed her PhD at Istanbul Technical University, Department of Organic Chemistry. She has had a year of assistant ship at University of Ilinois at Chicago, The U.S.A during her course of Ph.D. studies. She is Assistant Professor at Faculty of Pharmacy, Department of Pharmaceutical Biotechnology, Bezmialem Vakif University, Istanbul-Turkey since 2014. She has published more than 15 papers in reputed journals, 2 chapters in international books and has edited a special issue with special emphasis on Nano Drug Delivery systems in an internationally indexed journal.
During the last decades delivering biologically active molecules using nano materials (nano drug delivery systems; NDDS), have gained increasing attention in a wide range of applications from sensing and imaging to treatment of disease. The superior properties of nano materials provide numerous feasibilities such as controlling the release of drugs, targeting and imaging of cancer tumors, increasing serum half-life of bioactive molecules, passing over Blood Brain Barrier etc. Targeting cancer tumor is the area, which has attracted the greatest interest. By targeting cancer side, it is possible to obtain a better efficacy with a lower dose of the chemotherapeutic agent. However, this would be possible only if the material used in synthesis of nano-drug delivery system is both biocompatible and biodegradable.
Nano-micelles made of amphiphilic materials are superior in all above-mentioned properties compared to other NDDS. They simultaneously form in aqueous media and this provides easy production especially in industrial scale. However, their application has been associated with some stability problems and not all amphiphilic materials are non-toxic. According to our studies, natural materials show the best toxicity profile in vivo and it is possible to enhance their stability using some other natural products as well. In this presentation, we will discuss synthesis and in vitro and in vivo evaluation of micelles made of organic natural materials such as phospholipids, chitosan and glycolipids. We also will compare their cytotoxicity and genotoxicity compared to synthetic polymers.
Faculty of Engineering and Institute of Nanotechnology and Advanced Materials, Bar-Ilan University,Israel.
Time : 11:20-12:05
Dror Fixler received his Ph.D. degree in 2003 from the Department of Physics, Bar-Ilan University, Israel. He is a member of the Faculty of Engineering and the Nano center of Bar-Ilan University. He has published over 70 original research papers and holds over 11 issued patents. His research interests include fluorescence measurements (FLIM and anisotropy decay), optical super resolution, high-end electro-optical system engineering and light-tissue interaction. Dr. Fixler received several international awards and organized and presented at over 20 international conferences.
Current medical treatments are largely based on statistics and time. In our talk we will present highly efficient probes describing patient-specific in vivo disease behaviors and therapy responses. Our method is based on gold nanoparticles (GNPs) that bind to fluorescent molecules and other chemical molecules. Using the plasmon properties of the GNPs, we control the optical signals obtainable from our constructs so that they will be able to respond to their surroundings in a sensitive manner. In addition in this method we will image our constructs using several modalities to emphasize their usefulness for in vivo detection in a variety of exciting biological research topics.
In our talk we will show several empanels aiming to present a new, simple and non-invasive method to detect, locate, and to treat several diseases. One example will be detection and treatment of atherosclerosis (AS) at its very early stages. We use GNPs combined with the diffusion reflection (DR) method to demonstrate the detection of vulnerable AS plaques. Our method is based on the fact that macrophages are a major component in the vulnerable plaque and are able to uptake metal nanoparticles that can be discovered by the DR system. In addition, it is well known that high density lipoprotein (HDL) reduces AS. Thus, the specific treatment of AS is presented, as the GNPs serve as drug carriers of HDL. Early and accurate non-invasive detection of AS plaques by DR method and GNPs may allow serially monitoring the rate of disease progression and thus tailoring therapeutic measures accordingly.
Time : 10:15-11:00
Tsung-Yen Tsai has completed her PhD from Texas A&M University in 1996. She worked for ITRI, Taiwan for 6 years as the division director and then transferred to Chung Yuan Christian University since 2002. She is the distinguished professor of Chemistry department. She has published more than 45 papers in SCIjournals, over 35 patents and has been serving as the project director to develop the pilot of new nanocomposites, cooperated with more than 30 companies.
PET is hydrophobic and semicrystalline polyester due to the presence of the aromatic ring in the polymeric structure. It shows high melting point and very good mechanical strength even numerous excellent properties such as good flexibility, thermal stability, fatigue resistance, high crystal-melting temperature, and low cost, etc. In recent years there is an increasing interest for the preparation of PET nanocomposites due to there extensive properties. The main industrial PET production is usually carried out two ways (a) bis-(2-hydroxyethyl) terephthalate (BHET) oligomerization, (b) esterification of terephthalic acid (TPA) or dimethyl terephthalate (DMT) with ethylene glycol (EG) by zinc or manganese acetate or Antimony compound as a catalyst. However, residual heavy-metal catalysts in PET products are harmful to the health, particularly when used in food or beverage packaging. Thus, without addition of the heavy-metal catalyst, the development of a new method for the rapid polymerization of PET synthesis is desirable. Fortunately, organically modified nanofillers (LDHs) provide an opportunity to solve the above mentioned problems. According to our previous research, we developed organo-modified various LDH used as a new catalyst without heavy metals to prepare new type of PET nanocomposites by in-situ preparation method. PET/LDH nanocomposite morphologies were determined by XRD, TEM. TEM and are exfoliated and intercalated with the layer by the PET molecules during in situ polymerization with various LDHs. This effect could be attributed to the better thermos mechanical, gas barrier properties of PET/LDH nanocomposites.