Hagit Sade has received her MSc in 2006 Bar-Ilan University and her work experience includes, among other things, a QC chemist position in the analytical laboratory of Fischer Pharmaceuticals, and an R&D chemist positions in Virdia, Ltd. She is currently working on her PhD degree under the supervision of Prof. Jean-Paul (Moshe) Lellouche in Bar-Ilan Univeristy.
WS2 and other transition metals dichalcogenides (TMD) nanostructures have superior tribological and mechanical properties. The interest of using them as additives to polymeric matrices is constantly rising. The challenge in successfully incorporating TMD nanostructures in polymeric matrices is that these nanostructures are fairly chemically inert. To date, the functionalization of TMD nanostructures has been less studied than the functionalization of their carbon equivalents. Within this field of research, the functionalization of TMD nanostructures with organic moieties is the least addressed. We present a new, simple method for the functionalization of WS2 NTs with conformal humin-like coatings of different thicknesses. We believe that the present study should expand the range of functionalization options for TMD nanostructures with organic moieties, and could lead to a more beneficial use of these nanostructures’ superior mechanical and other properties in existing and new applications.
Traditional micelles composed of amphiphilic molecules caused low drug loading and less drug stability. To improve the limitation, additionally lipid shell as stabilized to encapsulate micelle can improve high drug leakage and instability resulted from the drug only entrapped in the matrix of amphiphilic polymer. In this study, it was attempted to develop a lecithin stabilized micellar drug delivery system (LSM) for enhancing therapeutic efficacy and minimizing systemic toxicity of docetaxel (DTX). A novel lecithin stabilized micellar docetaxel (LSMD) was prepared by firstly forming a thin film of self assembling micelles containing DTX and subsequently hydrated with lecithin nanosuspension. The physical characteristics of optimized LSMD revealed in Fig 1(A) were summarized as the following: mean size<200nm; encapsulation efficiency>90%; drug loading>5%; stability after reconstitution at RT and 4 oC was >8 hs and >48 hs, respectively. The drug release profiles in Fig 1(B) shows that DTX released from LSMD was slower than that of Tynen (DTX solvent-based formulation) in PBS buffer containing 0.5% Tween 80. LSMD further shows better cytotoxicity than Tynen for CT26 in cell viability assay. The immunofluorescence staining assay indicated that the alpha-tubulin in DU145 treated with LSMD obviously was polymerized and the nucleus was fragmented. The in vivo antitumor efficacy of LSMD was evaluated in the C26 tumor-bearing mice mode. The Fig 1(C) demonstrated LSMD are more efficacious than Tynen. In vivo study, treatment with LSMD leads to high drug accumulation in tumor and maximal tolerance dose was two folds higher than Tynen. In conclusion, lecithin stabilized micellar (LSM) drug delivery systems could be a potential carrier for delivering hydrophobic chemotherapeutic agent that could enhance the efficacy of cancer chemotherapy and reduced toxicity